"Why do cancers spread" and "how do they get to prefer tissues" are two different questions. So technically there isn't so much a contradiction than a clarification of what "somehow" actually means. (More specifically they "just" inject the mice with lose cells, so "why do they move in the first place" isn't their concern How that would apply to "why some keep turning up in specific places depending on cancer type" is probably the "somehow" part, not the coughing part.Īnd to be fair this research seems to deal with the "how they get there" part more than the "how they get to move in the first place". Like I could see why coughing fits (or other physical impact) could disloge cells to THEN move around in the bloodstream. It sounds like something that isn't technically wrong applied to something entirely wrong. If we can understand why its attracting the cells, then couldnt we manipulate that same process for targeted treatment? Really cool stuff. I wonder though could it be used as a calling card for other treatments. I know they will start with blocking that protein to see what the results are. The protein may not be only factor involved, Greenblatt says, “but it’s an important one in driving tumor cells to the spine. The newly identified spinal stem cells, found in both mice and humans, secrete a protein called MFGE8 that acts as a tumor attractant, the team discovered, drawing cancer cells to spinal tissue. Happy he didnt buy into that and went looking for the real reason. Seriously? They were still teaching that coughing was moving the cancer cells? A theory from 1940? Ugh. But for him and his team, “that didn’t make sense to us scientifically. It’s what Greenblatt learned when he was a medical student. One idea proposed in 1940, that actions like coughing jolt blood off course and somehow send cancerous cells to the vertebrae, still hangs on today. New to reddit? Click here! Get flair in /r/science Previous Science AMA'sĭoctors have known for decades that some cancers preferentially seek out the spine, Greenblatt says, but no one has had a good explanation for why. Repeat or flagrant offenders will be banned.Comments dismissing established findings and fields of science must provide evidence. Criticism of published work should assume basic competence of the researchers and reviewers The Ras-MAPK pathway is aberrantly regulated in cancer and developmental diseases called RASopathies.Non-professional personal anecdotes will be removed.No off-topic comments, memes, low-effort comments or jokes.All submissions must have flair assigned.No blogspam, images, videos, or infographics.Research must be less than 6 months old.No editorialized, sensationalized, or biased titles.No summaries of summaries, re-hosted press releases, or reposts.Directly link to published peer-reviewed research or media summary.
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